Problems with D Supplements & Tests
Bonnie Sanjanwala ·Admin of the FB group
Secosteroid Hormone D
This research by Trevor Marshall is so important to understand how low levels of 25D do not equate to an empty tank that needs to be refilled. The body adjusts vitamin D levels according to it’s needs at the time and supplementing at a time when the body doesn’t need or want it makes disease worse.
Vitamin D supplements are immunosuppressive which shuts down the body’s ability to fight off infections and disease. This is the opposite of what most doctors say, that is if your 25D is low, the simple and logical fix is to supplement and raise it - sometimes by a lot. Nope, it’s not that simple.
Vitamin D Deficiency Study Raises New Questions About Disease And Supplements
The paper explains how the Vitamin D Nuclear Receptor (VDR) acts in the repression or transcription of hundreds of genes, including genes associated with diseases ranging from cancers to multiple sclerosis.
"The VDR is at the heart of innate immunity, being responsible for expression of most of the antimicrobial peptides, which are the body’s ultimate response to infection," Marshall said.
"Molecular biology is now forcing us to re-think the idea that a low measured value of vitamin D means we simply must add more to our diet. Supplemental vitamin D has been used for decades, and yet the epidemics of chronic disease, such as heart disease and obesity, are just getting worse."
"Our disease model has shown us why low levels of vitamin D are observed in association with major and chronic illness," Marshall added.
"Vitamin D is a secosteroid hormone, and the body regulates the production of all it needs. In fact, the use of supplements can be harmful, because they suppress the immune system so that the body cannot fight disease and infection effectively."
Marshall's research has demonstrated how ingested vitamin D can actually block VDR activation, the opposite effect to that of Sunshine.
Instead of a positive effect on gene expression, Marshall reported that his own work, as well as the work of others, shows that quite nominal doses of ingested vitamin D can suppress the proper operation of the immune system.
It is a different metabolite, a secosteroid hormone called 1,25-dihydroxyvitamin D, which activates the VDR to regulate the expression of the genes.
Under conditions that exist in infection or inflammation, the body automatically regulates its production of all the vitamin D metabolites, including 25-hydroxyvitamin D, the metabolite which is usually measured to indicate vitamin D status.
Vitamin D deficiency, long interpreted as a cause of disease, is more likely the result of the disease process, and increasing intake of vitamin D often makes the disease worse.
"Dysregulation of vitamin D has been observed in many chronic diseases, including many thought to be autoimmune," said J.C. Waterhouse, Ph.D., lead author of a book chapter on vitamin D and chronic disease.
"We have found that vitamin D supplementation, even at levels many consider desirable, interferes with recovery in these patients."
"We need to discard the notion that vitamin D affects a disease state in a simple way," Marshall said.
"Vitamin D affects the expression of over 1,000 genes, so we should not expect a simplistic cause and effect between vitamin D supplementation and disease. The comprehensive studies are just not showing that supplementary vitamin D makes people healthier."
Journal reference: Marshall TG. Vitamin D discovery outpaces FDA decision making. Bioessays. 2008 Jan 15;30(2):173-182 [Epub ahead of print] Online ISSN: 1521-1878 Print ISSN: 0265-9247 PMID: 18200565
Secosteroid Hormone D
This research by Trevor Marshall is so important to understand how low levels of 25D do not equate to an empty tank that needs to be refilled. The body adjusts vitamin D levels according to it’s needs at the time and supplementing at a time when the body doesn’t need or want it makes disease worse.
Vitamin D supplements are immunosuppressive which shuts down the body’s ability to fight off infections and disease. This is the opposite of what most doctors say, that is if your 25D is low, the simple and logical fix is to supplement and raise it - sometimes by a lot. Nope, it’s not that simple.
Vitamin D Deficiency Study Raises New Questions About Disease And Supplements
The paper explains how the Vitamin D Nuclear Receptor (VDR) acts in the repression or transcription of hundreds of genes, including genes associated with diseases ranging from cancers to multiple sclerosis.
"The VDR is at the heart of innate immunity, being responsible for expression of most of the antimicrobial peptides, which are the body’s ultimate response to infection," Marshall said.
"Molecular biology is now forcing us to re-think the idea that a low measured value of vitamin D means we simply must add more to our diet. Supplemental vitamin D has been used for decades, and yet the epidemics of chronic disease, such as heart disease and obesity, are just getting worse."
"Our disease model has shown us why low levels of vitamin D are observed in association with major and chronic illness," Marshall added.
"Vitamin D is a secosteroid hormone, and the body regulates the production of all it needs. In fact, the use of supplements can be harmful, because they suppress the immune system so that the body cannot fight disease and infection effectively."
Marshall's research has demonstrated how ingested vitamin D can actually block VDR activation, the opposite effect to that of Sunshine.
Instead of a positive effect on gene expression, Marshall reported that his own work, as well as the work of others, shows that quite nominal doses of ingested vitamin D can suppress the proper operation of the immune system.
It is a different metabolite, a secosteroid hormone called 1,25-dihydroxyvitamin D, which activates the VDR to regulate the expression of the genes.
Under conditions that exist in infection or inflammation, the body automatically regulates its production of all the vitamin D metabolites, including 25-hydroxyvitamin D, the metabolite which is usually measured to indicate vitamin D status.
Vitamin D deficiency, long interpreted as a cause of disease, is more likely the result of the disease process, and increasing intake of vitamin D often makes the disease worse.
"Dysregulation of vitamin D has been observed in many chronic diseases, including many thought to be autoimmune," said J.C. Waterhouse, Ph.D., lead author of a book chapter on vitamin D and chronic disease.
"We have found that vitamin D supplementation, even at levels many consider desirable, interferes with recovery in these patients."
"We need to discard the notion that vitamin D affects a disease state in a simple way," Marshall said.
"Vitamin D affects the expression of over 1,000 genes, so we should not expect a simplistic cause and effect between vitamin D supplementation and disease. The comprehensive studies are just not showing that supplementary vitamin D makes people healthier."
Journal reference: Marshall TG. Vitamin D discovery outpaces FDA decision making. Bioessays. 2008 Jan 15;30(2):173-182 [Epub ahead of print] Online ISSN: 1521-1878 Print ISSN: 0265-9247 PMID: 18200565
