B Vitamins:
Methylation and NAD
Many say the ultimate rejuvenator is NAD, based on the use of forms of niacin, vitamin B3, that are part of the mitochondria of every cell of every organ and function that affect every symptom.
NAD also lengthens telomeres to extend healthy aging, beyond increasing energy and being a part of the cure of potentially anything.
The big problem is that NAD must be balanced with methylation, which involves with numerous B vitamins, cofactors and other things.
Too much NAD suppresses methylation and can lead to depressed mood and eventually liver damage, as methylation is important in brain function and the liver’s function of detoxification.
The problem with methylation is its complexity as a number of sources cofactors working together in support of six methyl donors that also work together:
folate B9, vitamin B12, methionine, sam-e, betaine, and choline.
Cofactors to methyl donors also include B1, B2, B3, B6.
This is not meant as an exhaustive list.
You might be thinking, “What? Zinc and choline?” Hardly anyone is talking about these in this context.
Many people are just focused on the MTHFR mutations for folate utilization.
One thing this leads people to do is to take more of some form of folate to “compensate.”
But they often don’t tolerate it and sometimes do great damage.
It may be that the real problem is a cofactor deficiency to utlize folate, like B2, which Chris Masterjohn has for evidence for, posted on my personal FB page.
Many people report success with B2 while folate supplementation did not help, or maybe both helped together, along with other solutions.
The cofactor approach is holistic or systems thinking
Cofactor deficiencies are really the explanation for genetic damage as epi genetics being modified by the environment of nutrients.
Many people seem to be treating these epi genetics test as genetic determinism, leading to a mechanical understanding of “just take more to compensate.”
So the purpose of this post is to list cofactor nutrients that may be involved in an individual’s health puzzle, and we are all different so this is not meant as a shopping list of supplements and foods for everyone.
Zinc and copper are ratio dependent. I believe the RDA for copper has been underestimated, according to my own experimentation and testimonials of others. The fear of copper toxicity has been overstated.
Choline is of particular interest for its role in also forming bile that removes toxins processed through methylation and other detox pathways in the liver, to then stimulate bowel motility. Constipation and gall bladder pain are major symptoms of concern that depend on healthy bile formation and the neutralization of toxins to stimulate bile flow and not damage the gallbladder.
Indirect cofactors are basically all other nutrient deficiencies needed for the body to work.
Beginning with electrolytes magnesium, sodium and potassium are needed to tolerate other nutrients, as master cofactors.
Coming back to B3 for NAD, there are several forms:
I don’t give brand recommendations or personal advice in social media commetns because everyone has a different pattern and needs, so universal protocols are limited.
The point is to keep people thinking in terms of the body is only as strong as its weak links in nutrient deficiencies.
The aim here is to give people a wider set of nutrient cofactors to consider.
Some parameters for personal experimentation are:
There are big benefits for balancing methylation that are necessary to solve many health problems.
Strong methlylation is also important as a foundation for NAD boosting with forms of niacin.
NAD is part of the deepest energy of the body, the electron transport chain that energizes mitochondria.
The ultimate source of electrons is the sun as light photons are converted to electrons that charge the water of our bodies like a battery.
NAD also lengthens telomeres to extend healthy aging, beyond increasing energy and being a part of the cure of potentially anything.
The big problem is that NAD must be balanced with methylation, which involves with numerous B vitamins, cofactors and other things.
Too much NAD suppresses methylation and can lead to depressed mood and eventually liver damage, as methylation is important in brain function and the liver’s function of detoxification.
The problem with methylation is its complexity as a number of sources cofactors working together in support of six methyl donors that also work together:
folate B9, vitamin B12, methionine, sam-e, betaine, and choline.
Cofactors to methyl donors also include B1, B2, B3, B6.
This is not meant as an exhaustive list.
You might be thinking, “What? Zinc and choline?” Hardly anyone is talking about these in this context.
Many people are just focused on the MTHFR mutations for folate utilization.
One thing this leads people to do is to take more of some form of folate to “compensate.”
But they often don’t tolerate it and sometimes do great damage.
It may be that the real problem is a cofactor deficiency to utlize folate, like B2, which Chris Masterjohn has for evidence for, posted on my personal FB page.
Many people report success with B2 while folate supplementation did not help, or maybe both helped together, along with other solutions.
The cofactor approach is holistic or systems thinking
Cofactor deficiencies are really the explanation for genetic damage as epi genetics being modified by the environment of nutrients.
Many people seem to be treating these epi genetics test as genetic determinism, leading to a mechanical understanding of “just take more to compensate.”
So the purpose of this post is to list cofactor nutrients that may be involved in an individual’s health puzzle, and we are all different so this is not meant as a shopping list of supplements and foods for everyone.
Zinc and copper are ratio dependent. I believe the RDA for copper has been underestimated, according to my own experimentation and testimonials of others. The fear of copper toxicity has been overstated.
Choline is of particular interest for its role in also forming bile that removes toxins processed through methylation and other detox pathways in the liver, to then stimulate bowel motility. Constipation and gall bladder pain are major symptoms of concern that depend on healthy bile formation and the neutralization of toxins to stimulate bile flow and not damage the gallbladder.
Indirect cofactors are basically all other nutrient deficiencies needed for the body to work.
Beginning with electrolytes magnesium, sodium and potassium are needed to tolerate other nutrients, as master cofactors.
Coming back to B3 for NAD, there are several forms:
- Niacin: low formaton of NAD
- Niacinimide: low formation of NAD
- nicotinamide riboside: high formation of NAD
- Nmn: niacinamide mononucleotide: high formation of NAD
- Inositol hexanicotinate: almost forgotten but I believe high in formation of NAD
- NAD itself: not necessarily as absorbable due to size.
I don’t give brand recommendations or personal advice in social media commetns because everyone has a different pattern and needs, so universal protocols are limited.
The point is to keep people thinking in terms of the body is only as strong as its weak links in nutrient deficiencies.
The aim here is to give people a wider set of nutrient cofactors to consider.
Some parameters for personal experimentation are:
- Identifying nutrient deficiencies
- Selecting best source of nutrients
- Quantifying ideal amounts which are often way less to start with than the mega doses sold in pills.
- Complete solutions based on all cofactors.
- Implementation progression: one thing at a time or all at once because they are so interdependent?
There are big benefits for balancing methylation that are necessary to solve many health problems.
Strong methlylation is also important as a foundation for NAD boosting with forms of niacin.
NAD is part of the deepest energy of the body, the electron transport chain that energizes mitochondria.
The ultimate source of electrons is the sun as light photons are converted to electrons that charge the water of our bodies like a battery.
Eat to energize, detoxify & immunize.
Move to circulate, align, & relax.
Primal Rejuvenation Health Coaching
Find out what you get in a
Free Assessment
See how I support you fully in
Health Coaching Steps
I work over video: Facebook, Zoom, Google, from Michigan, USA
[email protected]
Follow me on FACEBOOK:
choose “See First” to get all notifications. blog posts
INSTAGRAM
Primal Rejuvenation
Systematic
enough to make a difference
Simple
enough to implement
Sensitive
to individual needs
Move to circulate, align, & relax.
Primal Rejuvenation Health Coaching
Find out what you get in a
Free Assessment
See how I support you fully in
Health Coaching Steps
I work over video: Facebook, Zoom, Google, from Michigan, USA
[email protected]
Follow me on FACEBOOK:
choose “See First” to get all notifications. blog posts
Primal Rejuvenation
Systematic
enough to make a difference
Simple
enough to implement
Sensitive
to individual needs
