B Vitamins:
Methylation and NAD
Many say the ultimate rejuvenator is NAD--Nicotinamide Adenine Dinucleotide--made from niacin, vitamin B3, that is part of the mitochondria of every cell of every organ and function that affects every symptom.
NAD is part of the deepest energy of the body, the electron transport chain that energizes mitochondria.
NAD also lengthens telomeres to extend healthy aging, beyond increasing energy and being a part of the cure of potentially anything.
The big problem is that NAD must be balanced with methylation, which involves numerous B vitamins, cofactors and other things.
Too much NAD suppresses methylation and can lead to depressed mood and eventually liver damage, as methylation is important in brain function and the liver’s function of detoxification.
The problem with methylation is its complexity as a number of cofactors working together in support of six methyl donors that also work together:
folate B9, vitamin B12, methionine, sam-e, trimethylglycine, and choline.
Cofactors to methyl donors also include B1, B2, B3, B6.
This is not meant as an exhaustive list.
Many people are just focused on the MTHFR mutations for folate utilization.
One thing this leads people to do is to take more of some form of folate to “compensate.”
But they often don’t tolerate it and sometimes do great damage.
It may be that the real problem is a cofactor deficiency to utilize folate, like B2, which Chris Masterjohn has provided evidence for, posted on my personal FB page.
Many people report success with B2 while folate supplementation did not help, or maybe both helped together, along with other solutions.
Indirect cofactors are basically all other nutrient deficiencies needed for the body to work.
Beginning with electrolytes magnesium, sodium and potassium are needed to tolerate other nutrients, as master cofactors.
Coming back to B3 for NAD, there are several forms:
The cofactor approach is holistic or systems thinking
Cofactor deficiencies could be an explanation for genetic damage as epigenetics being modified by the environment of nutrients.
Many people seem to be treating these epigenetics tests as genetic determinism, leading to a mechanical understanding of “just take more to compensate.
NAD is part of the deepest energy of the body, the electron transport chain that energizes mitochondria.
NAD also lengthens telomeres to extend healthy aging, beyond increasing energy and being a part of the cure of potentially anything.
The big problem is that NAD must be balanced with methylation, which involves numerous B vitamins, cofactors and other things.
Too much NAD suppresses methylation and can lead to depressed mood and eventually liver damage, as methylation is important in brain function and the liver’s function of detoxification.
The problem with methylation is its complexity as a number of cofactors working together in support of six methyl donors that also work together:
folate B9, vitamin B12, methionine, sam-e, trimethylglycine, and choline.
Cofactors to methyl donors also include B1, B2, B3, B6.
This is not meant as an exhaustive list.
Many people are just focused on the MTHFR mutations for folate utilization.
One thing this leads people to do is to take more of some form of folate to “compensate.”
But they often don’t tolerate it and sometimes do great damage.
It may be that the real problem is a cofactor deficiency to utilize folate, like B2, which Chris Masterjohn has provided evidence for, posted on my personal FB page.
Many people report success with B2 while folate supplementation did not help, or maybe both helped together, along with other solutions.
Indirect cofactors are basically all other nutrient deficiencies needed for the body to work.
Beginning with electrolytes magnesium, sodium and potassium are needed to tolerate other nutrients, as master cofactors.
Coming back to B3 for NAD, there are several forms:
- Niacin: low formation of NAD
- Niacinamide: low formation of NAD
- nicotinamide riboside: high formation of NAD
- Nmn: niacinamide mononucleotide: high formation of NAD
- Inositol hexanicotinate: almost forgotten but I believe high in formation of NAD
- NAD itself: not necessarily as absorbable due to size.
- Taking NAD directly forces the body to utilize that amount, which may drain methylation: whereas, taking precursors allows the body to decide how much NAD to produce in a way that may be more regulated and balanced.
- NAD might not be the weakest link so taking it could only throw things off.
The cofactor approach is holistic or systems thinking
Cofactor deficiencies could be an explanation for genetic damage as epigenetics being modified by the environment of nutrients.
Many people seem to be treating these epigenetics tests as genetic determinism, leading to a mechanical understanding of “just take more to compensate.
Eat to energize, detoxify & immunize.
Move to circulate, align, & relax.
Primal Rejuvenation Health Coaching
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See how I support you fully in
Health Coaching Steps
I work over video: Facebook, Zoom, Google, from Michigan, USA
[email protected]
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Primal Rejuvenation
Systematic
enough to make a difference
Simple
enough to implement
Sensitive
to individual needs
Move to circulate, align, & relax.
Primal Rejuvenation Health Coaching
Find out what you get in a
Free Assessment
See how I support you fully in
Health Coaching Steps
I work over video: Facebook, Zoom, Google, from Michigan, USA
[email protected]
Follow me on FACEBOOK:
choose “See First” to get all notifications. blog posts
Primal Rejuvenation
Systematic
enough to make a difference
Simple
enough to implement
Sensitive
to individual needs
